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I.はじめに
Carbamazepine(CBZ:商品名テグレトール)は抗けいれん剤や三叉神経痛・頑痛症などの疼痛発作抑制剤として使用する頻度が多い.CBZの副作用としてめまい・立ち眩み・集中力低下はしばしば経験する.しかしCBZはsyndrome of inap-propriate antidiuretic hormone(SIADH)を生じうる薬剤でもある.1980年代まではCBZによる低Na血症の報告が散見されるが4,5,9,10),最近ではその報告はほとんどない.今回われわれはCBZが原因となった低Na血症の2例を経験したので報告する.
Carbamazepine (CBZ) is a drug which can induce the syndrome of inappropriate antidiuretic hormone(SIADH). Until 1980's, there were reports regarding CBZ-induced SIADH, but it is rarely reported thesedays. We here report two cases of CBZ-induced SIADH. Hyponatremia in these cases was rapidly im-proved by withdrawal of administration of CBZ. According to the previous reports, the rate of hyponatre-mia in patients receiving CBZ is not small. It ranges from 4.8% to 31%. As CBZ is frequently used for pa-tients with epilepsy and neuralgia, not only their blood CBZ concentration but also their serum Na levelshould be monitored.
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