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Brain Metastasis of Rhabdomyosarcoma with Intratumorous Hemorrhage:A case report and literature review Shinji UENO 1 , Hiroaki ARAI 1 , Takehide ONUMA 1 , Akira KIKUCHI 2 , Ryo ICHINOHASAMA 3 1Departments of Neurosurgery, Sendai City Hospital 2Departments of Radiology, Sendai City Hospital 3Department of Pathology, Tohoku University Hospital Keyword: Metastatic brain tumor , Rhabdomyosarcoma , Thorax , Intratumorous hemorrhage , Adult pp.1125-1130
Published Date 1993/12/10
DOI https://doi.org/10.11477/mf.1436902493
  • Abstract
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A 56-year-old male suffered from primary rhabdomyo-sarcoma on the left internal thoracic wall, which was treated by chemotherapy, and local irradiation following biopsy. Four months after the diagnosis, he suddenly complained of headache and left paresthesia occurred followed by generalized convulsion and left hemiplegia. CT scan revealed a high density mass in the right pariet-al lobe. The patient was referred to our department and underwent emergency evacuation of the hematoma together with tumor removal. The pathological specimen showed spindle or oval-like cells with hypercellularity and some mitotic figures. Immunohistochemical study demonstrated that many cells were positive for desmin and myoglobin, which is specific to myogenic tumor. These characteristics were compatible with those of the primary thoracic lesion, and a diagnosis of metastatic rhabdomyosarcoma was made. Five weeks after the cra-niotomy, the metastatic brain tumor recurred in the same site and also in the bilateral occipital lobes. Although radiotherapy to the brain decreased the tumor size, the patient died of respiratory failure eleven and a half months after the initial diagnosis.

Sarcomas metastasizing to the brain are rare and only 16 cases of rhabdomyosarcoma metastasizing to the brain have been reported so far. Recent advances in che-motherapy, however, have been able to show the in-creased incidence of sarcoma metastasis to the brain. Therefore, the necessity of follow-up CT scan for sarco-ma patients of long survival is to be stressed, even if the patient shows no neurological symptoms.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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