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Prospective Dose-Escalation Study in Stereotactic Radiotherapy Utilizing a Linear Accelerator:Report from East Hokkaido Radiosurgery Study Group (EHRSSG) Hiroki SHIRATO 1 , Toyohiko ISU 2 , Yukihiko SHIMIZU 3 , Takeshi NISHIOKA 1 , Masa NONAKA 4 , Satoru ABE 5 , Shigeki MATSUMURA 6 , Tadashi SHIMIZU 1 , Wataru ICHIMURA 1 , Keishiro SUZUKI 1 , Toshikazu NANBU 7 , EAST HOKKAIDO 8 1Department of Radiology, Obihiro Kousei Hospital 2Department of Neurosurgery, Kushiro Rosai Hospital 3Department of Neurosurgery, Obihiro Daiichi Hospital 4Obihiro Neurosurgical Hospital 5Department of Radiology, Hokkaido University School of Dentistry 6Department of Neurosurgery, Obihiro Kyoukai Hospital 7Department of Radiology, Kushiro Rousai Hospital 8East Hokkaido Radiosurgery Study Group (EHRSSG) Keyword: Radiosurgoy , Fractionated stereotactic radiotherapy , Stereotactic boost , Linear accelerator pp.1089-1095
Published Date 1993/12/10
DOI https://doi.org/10.11477/mf.1436902487
  • Abstract
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Stereotactic radiotherapy utilizing a linear accelerator has been investigated. (1) Radiosurgery, (2) fractionated stereotactic radiotherapy, and (3) fractionated radiother-apy followed by stereotactic boost have been performed according to pathology, size, and prognosis of diseases. Accuracy in localization of the treatment center was within one milimeter using a CT simulator. From July, 1990 to December 1992, 69 lesions in 63 patients have been treated using the stereotactic radiotherapy accord-ing to prospective dose-escalation design. Five patients have experienced transient worsening of nerve palsy or headache, but these complications were self-limited. No late radiation damage was observed over a mean follow-up period of 12.5 months. Encouraging improvements were obtained in patients with metastasis, AVM, and acustic neurinoma although the follow-up period was too short to be conclusive. Stereotactic radiotherapy utilizing a linear accelerator is thus suggested as a safe and effec-tive approach providing that dose-volume-time rela-tionship is well controlled.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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