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Therapeutic Efficacy and Prognostic Factors in Diffuse Astrocytomas Takao WATANABE 1 , Chiaki KOMINE 1 , Takakazu YOKOYAMA 1 , Atsuo YOSHINO 1 , Yoichi KATAYAMA 1 1Department of Neurological Surgery, Nihon University School of Medicine Keyword: diffuse astrocytoma , prognosis , surgery , interferon—β , MGMT methylation , chemotherapy pp.767-773
Published Date 2003/7/10
DOI https://doi.org/10.11477/mf.1436902416
  • Abstract
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Diffuse astrocvtomas are slowly growing tumors with a relatively long overall survival. Considerable controversy exists as to the best therapeutic management for patients with such tumors. In the present study. we retrospectively analyzed a series of 64 patients with WHO grade II astrocytomas of the cerebral hemispheres. Gross total resection and interferon-β therapy were significantly associated with both longer progression free survival (PFS) and overall survival (OS). Immediate postoperative radiation therapy did not prolong either the PFS or OS.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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