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Neurological Surgery No Shinkei Geka Volume 29, Issue 5 （May 2001）

Neurological Surgery 脳神経外科 29巻5号（2001年5月発行）

Japanese English

症例

放射線治療が著効したgliomatosis cerebriの1例 A Case of Gliomatosis Cerebri : Remarkable Improvement after Radiation Therapy 秦暢宏 ¹ , 勝田俊郎 ¹ , 井上亨 ¹ , 上原智 ² , 竹下盛重 ³ Nobuhiro HATA ¹ , Toshiro KATSUTA ¹ , Tooru INOUE ¹ , Satoshi UEHARA ² , Morishige TAKESHITA ³ ¹国立病院九州医療センター臨床研究部脳神経外科 ²国立病院九州医療センター放射線科 ³国立病院九州医療センター病理 ¹Departments of Neurosurgery Clinical Research Institute, National Kyushu Medical Center Hospital ²Radiology Clinical Research Institute, National Kyushu Medical Center Hospital ³Pathology Clinical Research Institute, National Kyushu Medical Center Hospital キーワード： gliomatosis cerebri , radiation , diffuse glioma , multicentric glioma Keyword: gliomatosis cerebri , radiation , diffuse glioma , multicentric glioma pp.409-414

発行日 2001年5月10日 Published Date 2001/5/10

DOI https://doi.org/10.11477/mf.1436902037

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Abstract 文献概要
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I．はじめに

　Gliomatosis cerebriは，きわめて予後の悪い疾患として知られているが，今回われわれは放射線治療が著効した症例を経験した．症例を提示するとともに，本疾患の診断と放射線治療に関して文献的考察を加え報告する．

A 30-year-old female case of gliomatosis cerebri, which showed remarkable improvement after radiation therapy is reported. The lesion had spread widely in the frontal and parietal lobes of both sides, causing diffuse swelling of the cerebral hemispheres. A specimen obtained by open biopsy revealed diffuse prolif- eration of astrocytic (GFAP positive) tumor cells, associated with little tissue destruction. After whole- brain radiation of 60 Gy, the lesion shrunk gradually but markedly. Hemiparesis and milddementia, whichthe patient had experienced before treatment,subsided completely within 6 months, until she wasable torestart her job as a dentist. Although gliomatosiscerebri is thought to have a poor prognosis, thiscase de-monstrates the potential of radiotherapy for thisdisease. Factors which may lead to a better outcomearediscussed.