臨床概念としてのgliomatosis cerebri

Gliomatosis Cerebri as a Clinical Entity

Gliomatosis cerebriは3葉以上の白質に浸潤像を持つ特殊な神経膠腫の一亜型である。現在ではMRIを中心とする画像診断で病変の広がりを確認し，手術材料の病理診断で神経膠腫細胞を確認すればよい。広範な病変の広がりに比べて臨床症状は軽微であり，臨床概念として重要であるが，形態学的診断と分子病理学的診断とは乖離があり，新しいWHO脳腫瘍病理分類のentityからは削除された。

Abstract

Gliomatosis cerebri is a rare subtype of glioma involving more than three lobes of the central nervous system. Currently, diagnosis of gliomatosis cerebri can be confirmed pathologically, surgically, or with magnetic resonance imaging that shows high-signal areas expanding to the cerebral hemisphere, brain stem, cerebellum, and spinal cord. Although this disease has great clinical importance, it has recently been removed from the revised WHO classification of Tumors of the Central Nervous System (2016) owing to divergence between its morphological features and molecular profiles.