急性期頭部外傷患者における血清Neuronspecific Enolase値測定の意義

Significance of Serum Neuron-specific Enolase Levels after Head Injury

I．はじめに

　解糖系酵素であるenolaseの中で，γ—subunitを有するものはneuron-specific enolase（NSE）と呼ばれ，神経細胞と軸索に局在し，神経損傷時には髄液や血中に逸脱するとされている．これに関する実験的^2,13），臨床的報告^3,5,7,11）は散見されるが，頭部外傷臨床例におけるまとまった報告はいまだない．今回われわれは，頭部外傷患者において入院直後の血清NSE値を測定し，その臨床的意義について検討したので報告する．

Enolase is an enzyme involved in glycolysis and neuronspecific enolase (NSE) has two types of isoen-zyme (αγ and γγ enolase). Found in nerve cells and ax-ons, the NSE is reported to be released into the serum and cerebrospinal fluid following nerve injury. We re-cently analyzed serum NSE levels in 47 patients with solitary head injury who were transported to our center immediately after injury. There were 35 men and 12 women, with a mean age of 35.1 years. In each case, blood was sampled within 8 hours after injury.