頭部外傷患者の臨床経過と髄液酵素活性値

CSF Enzyme Activities in Patients with Head Injury:especially on GOT, GPT, LDH and CPK

Ⅰ．緒言

　頭部外傷においてcreatine（Cr），creatinine（Crn），17-KS，17-OHCSなどの尿中排泄値と臨床像の推移との間にかなり相関がみられ，意識障害例・重症例では，正常時にはほとんどみられないCrが多く排泄され予後不良の指標となる点についてはすでに発表して来た¹⁷が，さらに脳脊髄液や血清の諸酵素GOT，GPT，LDH，CPKとの関連についても検索し始め予後経過を診る上で興味ある知見を得ており，この尿中排泄値変動との関連などをも含めて種々考察を加え述べてみる．

In our studies on patients with head injury, it was noted that there are some correlations between their chinical courses and the urinary excretion of creatine (Cr), creatinine (Cr,) 17-ketosteroid and 17 hydroxycorticosteroid.

We observed the high urinary excretion of Cr in patients with severe head injury while almost negative in a mild case.

We reported those facts in 1974.

Also noted in patients with head injury is the relationship between the enzyme-activities (GOT, GPT,LDH and CPK) in the cerebrospinal fluid and their clinical courses.