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Imaging Techniques to Assess Cerebral Perfusion and Metabolism in Chronic Cerebral Ischemia Ikuko UWANO 1 , Makoto SASAKI 1 1Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University Keyword: PET , SPECT , 酸素摂取率 , 脳血液量 , 血管反応性 , oxygen extraction fraction , cerebral blood volume , cerebrovascular reactivity pp.719-726
Published Date 2022/7/10
DOI https://doi.org/10.11477/mf.1436204613
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 The assessment of cerebral perfusion and metabolism is crucial in evaluating the indications for bypass surgery and other revascularization procedures in patients with chronic hemodynamic cerebral ischemia. In particular, it is necessary to detect misery perfusion(Powers' stage Ⅱ), which is defined as an increased oxygen extraction fraction and increased cerebral blood volume or impaired cerebrovascular reactivity, with a constant cerebral metabolic rate of oxygen. Among the imaging techniques available for this purpose, 15O-positron emission tomography(PET)and acetazolamide-challenge single-photon emission computed tomography(SPECT)remain the de facto standards; however, these have substantial limitations such as invasiveness and the risk of severe adverse effects. Recently, several less invasive, easy-to-use techniques, such as perfusion computed tomography and magnetic resonance(MR)imaging, arterial spin labeling, quantitative susceptibility mapping, intravoxel incoherent motion, MR spectroscopy, and single-slab MR angiography, have also been introduced. These techniques may serve as alternatives to PET or SPECT if validation studies are successful and standardization among vendors is achieved.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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