雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Basal Ganglia and Circuit Function:How Does the Ablation or Deep Brain Stimulation(DBS)Work? Nagako MURASE 1 , Hidehiro HIRABAYASHI 2 1Department of Neurology, National Hospital Organization Nara Medical Center 2Department of Neurosurgery, National Hospital Organization Nara Medical Center Keyword: 並列回路 , 体性局在 , 直接路と間接路 , 発火頻度モデル , 異常同期 , parallel loop , somatotopy , direct and indirect pathways , rate model , abnormal synchronization pp.712-723
Published Date 2021/7/10
DOI https://doi.org/10.11477/mf.1436204449
  • Abstract
  • Look Inside
  • Reference

 The basal ganglia(BG)is composed of four parallel loops: the motor, oculomotor, associative, and limbic loops. The motor loop starts from the cortex, travels through the BG and thalamus, and returns to the same area of the cortex with somatotopic organization. The striatum is the major input nucleus of the cortex, and the internal segment of the globus pallidus(GPi)is the main output nucleus. BG is explained by the direct and indirect pathways, and these excitatory or inhibitory pathways are used for several disease models. In Parkinson's disease(PD), dopamine deficiency acts on both direct and indirect pathways to cause the neuronal activity of GPi to becomes disinhibited. Pallidotomy, an effective surgery to improve Parkinsonism, aimed to destroy this hyperactive state. This is based on the rate model. However, a simian PD model with MPTP-treated monkeys exhibited increased GPi activity during effective stimulation of subtalamic nucleus(STN)-DBS, which makes it difficult to explain the pathophysiology of PD based only on the rate model. Instead, the alterative model is now widely prevailing. Local field potentials recorded from the DBS leads implanted in GPi and/or STN uncovered the abnormally synchronized activity in the β range(β oscillation)and abnormal co-synchronization between these nuclei, which is believed to be important in the pathophysiology of PD.


Copyright © 2021, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有