雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Leptomeningeal Dissemination in Patients with Pituitary Metastasis from Breast Cancer Nakamasa HAYASHI 1 , Koichi MITSUYA 1 , Hideyuki HARADA 2 , Junichiro WATANABE 3 , Tetsuo NISHIMURA 2 , Yoko NAKASU 1 1Division of Neurosurgery, Shizuoka Cancer Center 2Division of Radiation Oncology, Shizuoka Cancer Center 3Division of Breast Oncology, Shizuoka Cancer Center Keyword: breast cancer , diabetes insipidus , leptomeningeal carcinomatosis , pituitary metastasis , radiation pp.371-376
Published Date 2016/5/10
DOI https://doi.org/10.11477/mf.1436203293
  • Abstract
  • Look Inside
  • Reference

 Pituitary metastases are uncommon complications of systemic cancer and account for only 1% of pituitary lesions. Breast cancer is one of the most common tumors to metastasize to the pituitary gland. A multidisciplinary approach that calls for close collaboration among oncologists, neurosurgeons, radiologists, and endocrinologists is mandatory for diagnosis and treatment of pituitary metastasis. From 2002 through 2013, 6 patients with pituitary metastases were treated at Shizuoka Cancer Center Hospital. The patients' age at presentation ranged from 45 to 75 years(average 59 years). Five of 6 patients had symptoms:anterior pituitary insufficiency in 4, diabetes insipidus in 3, and visual deficits in 2 patients. Five patients had other metastases at the time of presentation. Local irradiation to the metastatic lesion was adopted in 4, and whole brain irradiation was in 2 patients. In all cases, local control was achieved after irradiation, however, the pituitary insufficiency did not recover. Two of 4 patients treated with local irradiation suffered from meningeal dissemination within 5 months after treatment, and died at 8 and 11 months after diagnosis of pituitary metastasis, respectively. The patients treated with whole brain irradiation had longer survival periods. Early diagnosis, endocrinological management, and radiation therapy improve the quality of life in patients suffering from pituitary metastasis. Whole brain irradiation may be favorable in order to prevent meningeal dissemination.


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有