Neurological Surgery No Shinkei Geka Volume 44, Issue 3 (March 2016)

Posterior Reversible Encephalopathy Syndrome Associated with Cancer Therapy Koichi MITSUYA 1 , Yoko NAKASU 1 , Nakamasa HAYASHI 1 , Hirofumi YASUI 2 , Takashi IKEDA 3 , Shiho KUJI 4 , Yusuke ONOZAWA 5 , Masahiro ENDO 6 1Division of Neurosurgery, Shizuoka Cancer Center 2Division of Gastrointestinal Oncology, Shizuoka Cancer Center 3Division of Hematological Oncology, Shizuoka Cancer Center 4Division of Gynecology, Shizuoka Cancer Center 5Division of Oncology of Unknown Primary, Shizuoka Cancer Center 6Division of Diagnostic Radiology, Shizuoka Cancer Center Keyword: auto-regulation , cancer , epilepsy , MRI , posterior reversible encephalopathy syndrome pp.211-219
Published Date 2016/3/10
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 Posterior reversible encephalopathy syndrome(PRES)is a subacute neurological syndrome typically manifesting with headache, cortical blindness, and seizures. This syndrome is associated with risk factors such as malignant hypertension, eclampsia, and renal failure. Numerous case reports depict its occurrence in cancer patients. The direct causal mechanisms of PRES in cancer patients have not yet been identified. Cytotoxic chemotherapy may cause direct endothelial damage, which would impact the blood brain barrier. Angiogenesis inhibitors also cause elevation in blood pressure;this is significant, because PRES onset may be solely related to hypertension. An increased number of case reports involving new molecular targeted agent suggests that incidence of PRES as an oncological emergency may increase in the future.

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Neurological Surgery 脳神経外科
44巻3号 (2016年3月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院