Vasogenic brain edemaの発生・吸収に関する研究

A Mechanism of Development and Resolution of Vasogenic Brain Edema

I．はじめに

　すでにわれわれは，白質内のvasogenic brain edemaはdiffusionではなくbulk flowにより進展する^{2,9,10），12-15）}ことを発表してきたが，今回さらにその研究を進めるため，エバンスブルーと³⁵S—チオ疏酸塩（以下³⁵S）でラベルした人工髄液を一定のスピードでネコ脳白質に注入した．これはいわば傷害部位の毛細血管から浮腫液が周囲白質に漏出するvasogenic brain edemaのモデルである．また組織内注入液が脳室にdrainされる量を計算するため脳室—大槽灌流を行い，大槽からの³⁵Sの量を計算した．

To investigate the mechanism of development and resolution of vasogenic brain edema, authors have infused the mock CSF containing ³⁵S-sodium thio-sulfate via a thin needle into the white matter of either normal cat's brain or into the edematous brain.

The animals which were used in these experiments were divided into four groups (L20, L45, C20, C45). In the groups of animals subjected to a cold lesion (L20, L45), a small craniotomy was performed over the right frontal pole. A cold injury edema was produced 24 hours prior to the experiment.