血液脳関門の機能と発生

Function and ontogeny of the blood-brain barrier

はじめに

　血液脳関門（以下BBBと略す）の実態とその選択的物質透過機能についてのべ，それが胎生期のいつ，いかに完成し，どのように物質透過機能の選択分化が起こってくるかを最近の知見に基づいて総説した。

Abstract

Recent advances in understanding site and structure of the blood-brain barrier (BBB), its specific functional selection for transport, and their ontogenic development are described in this paper.

The capillary wall in other organs than the brain is surrounded by leaky porous endothelia, from where the plasma content extravasates into the surrounding connective tissue stroma and drains via lymphatic vessels into the venous flow.