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Sustained-release Pellet of Vasodilators:Basic experiment Teizo OKUMURA 1,2 , Yoshifumi ODA 1 , Tetsuo ARIMITSU 1 , Koreaki MORI 1 1Department of Neurosurgery, Kochi Medical School Keyword: Vasospasm , Vasodilator , Silicon pellet , Subarachnoid hemorrhage pp.1265-1271
Published Date 1984/10/10
DOI https://doi.org/10.11477/mf.1436201924
  • Abstract
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We examined the efficacy of slow-release, and pro-longed diffusion silicone pellets mixed with papaverine hydrochloride in the treatment of cerebral vasospasms following subarachnoid hemorrhage.

In addition the diffusion of the other vasodilating agents (diltiazem and nicardipine) into the saline solution using the same silicone materials was also investigated.

Papaverine hydrochloride was either packed in silicone tubes (packed type) or polymerized with silicone elastomer, Silastic MDX-4-4210 (solid type). The solid type pellet is cylindrical (diameter 3 mm, length 30 mm) and contains 40 w/v% of pure powder of papaverine.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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