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Treatment of Vasospasm after Ruptured Cerebral Aneurysms by'Pellet-Cisternal-Drain: PCD' Containing Sustained-release Vasodilators Yoshifumi ODA 1 , Tsuneki KONISHI 1 , Teizou OKUMURA 2 , Yu KANG 2 , Haruhiko KIKUCHI 2 , Yoshinari KAMIJYO 3 1Department of Neurosurgery, Shiga Medical Center for Adult Diseases 2Department of Neurosurgery, Kyoto University Medical School 3Department of Neurosurgery, Otsu Red Cross Hospital Keyword: Vasospasm , Vasodilator , Silicon pellet , Subarachnoid hemorrhage , Calcium antagonist pp.965-970
Published Date 1988/7/10
DOI https://doi.org/10.11477/mf.1436202667
  • Abstract
  • Look Inside

Diltiazem or papaverine hydrochloride as vasodila-tors were polymerized with silicon polymer (MDX-4- 4210 : Dow Co.) . The silicon pellets containing the drugs were placed in cisternal drainage tubes made of silicon, and used for the continuous cisternal drainage after the operations of ruptured cerebral aneurysms.

This system was tentatively termed 'pellet-cisternal-drain ; PCD'.

The rate of diffusion of the drug from the pellets was examined in 30 patients who underwent surgery for ruptured cerebral aneurysms in the acute phase on the 0 - 4th postical days.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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