脳動脈瘤術後患者のてんかん発作発現頻度と抗てんかん剤の予防的投薬—第1報

The Incidence of Postoperative Epilepsy and Prophylactic Anticonvulsants in Patients with Intracranial Aneurysm

I．はじめに

　脳神経外科領域において，開頭術，頭部外傷後にてんかん発作が発現することは決して稀ではない．これらの発作を予知し予防することはわれわれ脳神経外科医に課せられた大きな課題の1つである．

　著者らは大脳皮質への手術侵襲が比較的少ない脳動脈瘤慢性期手術例において，術後てんかん発作の発現頻度を調べ，開頭術後の抗てんかん剤の予防的投与法について考察したので報告する．

The occurrence of epileptic seizures is not rareafter craniotomy. The authors examined the in-cidence of postoperative epilepsy in 150 patients ofintracranial aneurysm. Anticonvulsants were givento all patients after operation, but in 12 cases anti-convulsants were discontinued because of liver dys-function. One hundred and eight out of 138 cases(78%) were prescribed polypharmaceutically, and 30of 138 cases (22%) were monopharmaceutically.