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I.はじめに
bromocriptine(2-bromo-α-ergocriptine)は種々の原因による高prolactin(以下PRLと略)血症に対して著効を呈することが知られている.すなわち,血中PRL値の低下ないし正常化,およびこれに伴った,月経の再来,乳汁分泌の停止などである2).さらにPRL産生腺腫に対してbromocriptineを用いた場合,多くの症例で腺腫容積の縮小が認められる1,6,15).
一般にPRL産生腺腫は,他の腺腫に比し浸潤性発育の傾向を有する10).海綿静脈洞内への浸潤も頻繁にみられ,またmicroadenomaの段階でもすでに下垂体硬膜への浸潤を認めることが稀でない.
The authors reported a case of pneumocephalusinduced by bromocriptine (Bc) treatment for arecurrentinvasive prolactinoma.
The patient was a 38-year old man, who had beentreated for 12 years, with three times ofcraniotomiesand two times of irradiation therapies. CT scanshowed the recurrence of the tumor, which extendedinto bilateral middle fossa, left orbit and leftcerebello-pontine angle. Serum prolactin levels elevated to35,200 ng/ml.
Then Bc was administered in a dose of 5 mg/day.Serum PRL concentration fell to 2,090 ng/ml onemonth after the initiation of the treatment, when hecomplained of headache, nausea and vomiting.
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