脳神経外科領域におけるglucocorticoid投与法の検討（第1報）—脳神経外科手術前後の下垂体ホルモン分泌能について

Clinical Evaluation on Glucocorticoid Administration in Neurosurgical Patients

Ⅰ．緒言

　脳神経外科領域では主として脳浮腫の予防あるいは治療の目的で比較的大量のglucocorticoidがひろく用いられている．

　その臨床的効果および有用性については，これに携さわる臨床家の認めるところとなっているが，その使用量，投与方法，副作用，適応，禁忌などについて系統的な検討はなされておらず，脳浮腫の発生する状況に応じて経験的に使用されているのが現状である．

Anterior pituitary function tests (ITT, TRH test and LH-RH test) were performed on 10 patients with intracranial lesions other than hypothalamo-pituitary tumors. These lesions were 8 brain tumors and 2 aneurysms. Relatively high doses of glucocorticoid were administered in pre- and post-operative period to all the cases.

Preoperative study showed a slightly low response of GH and PSH in one case and a low TSH response in 2 cases. ACTH, LH and PRL were normal in all the cases.

Postoperetive study was performed about 10 days after ceasing of glucocorticoid.