Neurological Surgery No Shinkei Geka Volume 37, Issue 3 (March 2009)

Spontaneous Regression of Primary Intracranial Germinoma: A Case Report Atsushi SATO 1 , Kaori SAKURADA 1 , Atsushi KUGE 1 , Miiko ITO 1 , Masahiro AKASAKA 1 , Takamasa KAYAMA 1 1Department of Neurosurgery,Yamagata University Faculty of Medicine Keyword: germinoma , spontaneous regression pp.277-282
Published Date 2009/3/10
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 Here we report a case in which an intracranial germinoma displayed spontaneous regression.

 An 11-year-old boy presented with polyuria and headache. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed tumors in the suprasellar and pineal regions, and obstructive hydrocephalus. As repeat MRI demonstrated shrinkage of these tumors, resection was deferred. The patient was discharged and followed up with serial MRI. The tumor continued to regress for three weeks; however, the patient was readmitted due to tumor regrowth. We performed endoscopic biopsy, and histopathologic diagnosis was germinoma. The patient underwent three courses of combined chemotherapy and radiotherapy, and complete response was achieved. Although the precise cause of the transient regression is unknown, intracranial germinoma may occasionally undergo spontaneous regression.

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Neurological Surgery 脳神経外科
37巻3号 (2009年3月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院