自然退縮を呈した鞍上部・松果体部germinomaの1例

Spontaneous Regression of Primary Intracranial Germinoma: A Case Report

Ⅰ．はじめに

　悪性腫瘍において自然退縮を呈する頻度は極めて稀であり，6～10万人に1人と報告されている³⁾．今回われわれは，自然退縮を認めた鞍上部・松果体germinomaの稀な1例を経験したので文献的考察を加え報告する．

　Here we report a case in which an intracranial germinoma displayed spontaneous regression.

　An 11-year-old boy presented with polyuria and headache. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed tumors in the suprasellar and pineal regions, and obstructive hydrocephalus. As repeat MRI demonstrated shrinkage of these tumors, resection was deferred. The patient was discharged and followed up with serial MRI. The tumor continued to regress for three weeks; however, the patient was readmitted due to tumor regrowth. We performed endoscopic biopsy, and histopathologic diagnosis was germinoma. The patient underwent three courses of combined chemotherapy and radiotherapy, and complete response was achieved. Although the precise cause of the transient regression is unknown, intracranial germinoma may occasionally undergo spontaneous regression.