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Bilateral Thalamic Glioma in an Adult: A Case Report and Review of the Literature Ken-ichiro IWAMI 1 , Toru ARIMA 1 , Fumiharu OOKA 1 , Takumi ASAI 1 , Masao TAMBARA 1 , Toru TAKAOKA 1 1Department of Neurosurgery,Okazaki Municipal Hospital Keyword: bilateral thalamic glioma , adult , diffuse astrocytoma , temozolomide , radiation therapy pp.285-290
Published Date 2009/3/10
DOI https://doi.org/10.11477/mf.1436100911
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 We report a case of a 36-year-old woman who had a rare bilateral thalamic glioma (BTG). She complained of memory disorder. T1-weighted magnetic resonance imaging revealed enlarged bilateral thalami with homogenous isointensity and no contrast enhancement. Histological examination of the biopsy specimen identified diffuse astrocytoma (WHO gradeⅡ).

 BTG is a rare variant of thalamic neoplasms, which can be distinguished clinically and radiologically from other gliomas. In most of the reported cases, the presenting symptoms were cognitive impairment varying from personality changes to frank dementia. Death usually occurs within two years after onset, independently of adjuvant therapy such as radiotherapy and chemotherapy. On neuroimaging, all of the BTG had a similar appearance, with both thalami being symmetrically enlarged.

 Our patient has been given radiotherapy and concominant and adjuvant temozolomide in Stupp's regimen. At the time of this writing (5 months after the consultation), there are no neurological symptoms, and no changes on neuroimaging.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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