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我々は急性ブロバリン中毒患者の髄液中ブローム量の推移を追究する途中で,正常の髄液中に既に大量のブロームが存在する事を知つた。その値は血液中ブローム量の数倍以上である。正常の髄液ブローム値は便宜上急性虫炎,陳旧性の整形外科的な四肢疾患等の腰椎穿刺液を使用した。
各種脳疾患について髄液中ブロームを測定して「てんかん」患者の髄液中ブロームが他に比して著しく少なく,痙攣に依り減少する事を臨床的,実験的に確めた。
A new quantitive method of bromide which wasdevised by the present author was Published atthe 85th meeting of the Japan Society of Biochemi-stry.
Determination of bromide was made clinicallyon 80 cases using cerebrospinal fluid and blood.The average normal cerebronominal fluid was 7.6mg/dl and the blood 0.9 mg/dl in average. Itwas revealed several times that bromide containedin the cerebrospinal fluid was as high as that ofthe blood.
Consequently, this new method was applied cli-nically for the diagnosis of craniocerebral injuries,brain turner, epilepsy or other mental diseases.The value of bromide in both cerebrospinal fluidand blood of the above diseases was measured bythis new method with the following results, incraniocerebral injuries, value of bromide in cere-bralspinal fluid increased about 2 times of normalvalue.
In epilepsy, it showed lower value than in anormal cases.
In brain tumor it was about 2.5 times as highas in a normal cases.
However, no remarkable variation on value of bromide in the blood were demonstrated in anycase of the above diseases.
It was as certained in the investigation thatmost of the bromide measured in cerebrospinalfluid was existing as an organic bromo-compoundwith was contaimed in non protein fraction.
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