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Developmental disorders of brain—Pathological and pathogenetical basis. Morimi SHIMADA 1 , Tsunekazu YAMANO 1 , Masaki OHNO 1 , Syosaku YAMAZAKI 1,2 1Department of Pediatrics, Shiga University of Medical Science 2National Shigaraki Sanatorium, Department of Pediatrics pp.924-935
Published Date 1988/12/10
DOI https://doi.org/10.11477/mf.1431906239
  • Abstract
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Pathological study on the autopsied brain of mentally and physically handicapped children discloses not infrequently various abnormalities in the histological and cytological levels, such as the abnormal cytoarchitecture, heterotopic neuronal nest, abnormal orientation of neuron and tortuous dendrite. These abnormalities have generally been considered to be resulted from the disorders of neuron production and/or mechanical obstruction of neuronal migration including abnormal radial fiber.

Our experimental studies on the microcephalic mouse, which was induced either by prenatal or by postnatal administration of cytosine arabinoside, indicated that the following factors play the impotant races for above mentioned histological and cytological changes : (1) Disturbance of the neuron production following the destruction of the matrix layer. (2) Regional and incomplete regenerated of the matrix layer and delayed neuron production in the regenerated matrix layer. (3) Unbalanced and plastic synaptogensis between the remaining neurons which have been produced prior to the destruction of the matrix layer, migrating young neurons produced in the regenerated matrix layer and the afferent fiber terminals which originate from subcortical neurons.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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