病巣修復の一過程としての脳と末梢神経の浮腫—胎児脳形成機序の再現

Brain and peripheral nerve edema as an initial stage of the lesion repair: Revival of the mechanisms of the normal development in the fetal brain

はじめに

　ほぼすべての脳疾患はその当初に，「脳腫脹」「脳浮腫」を伴い，脳浮腫は頭蓋内圧亢進を招き，しばしば病者を死に導くことから，脳神経疾患をめぐる最も普遍的，かつ不都合な病的状態とみなされ，今日に至っている。

　脳浮腫をめぐる研究は極めて多い。形態学的な面からだけでも，血脳関門（BBB）の破綻に関して，血管透過性に関して，さらに水分の貯溜は細胞内か，細胞外か等々に関しての，夥しい研究と討論が続けられてきた。

Abstract

Among many investigations on the brain edema, we think that the most important findings are the following : After the breakdown of blood-brain barrier (BBB), a large inflow of edema fluid passes into the brain tissue and accumulates within the abnormally distended "extracellular space". These findings were also true in our observa-tions. However, we thought an important point was how to understand these conditions. And we understood them that many neurons, as well as all other cellular elements, were separated from each other by the hematogenous edema fluid.