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Experimental and clinical study of cellular synchronization-radiation therapy for malignant brain tumors Nobuyuki SHITARA 1 1Department of Neurosurgery, Faculty of Medicine, University of Tokyo pp.119-131
Published Date 1978/2/10
DOI https://doi.org/10.11477/mf.1431904834
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Summary (Abstract)

 Since skipper reported on the cell cycle phase dependendy of chemotherapeutic agents, many rational regimen have been established in the treatment of malignant tumors. Sinclair and Terashima reported that radiation has different specificity on each cell cycle phase of tumor population, and the cells in the G2(post synthetic) and M (mitotic) phase are the most sensitive to cytocidal action of radiation.

 The knowledge of cell cycle phase specificity of chemotherapeutic agents and irradiation is important for advancing the regimen of treatment.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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