Bromouridine-antimetabolite-continuous intra-artcrial infusion-radiation therapy (BAR therapy) for malignant brain tumors Yoshimasa MIKI 1 1Department of Neurosurgery, Faculty of Medicine, University of Tokyo pp.111-118
Published Date 1978/2/10
DOI https://doi.org/10.11477/mf.1431904833
  • Abstract
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 The mechanism of the radiosensitizers and the theory of BAR therapy were reviewed. 5-bromo-2'-deoxyuridine (BUdR) is well known to be incorporated into the nuclei of cultured human brain tumor cells. And the facts that the tumor cells which have taken up BUdR into their nuclei become more radiosensitive and that a small amount of antimetabolite enhances the incorporation of BUdR had been confirmed.

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