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Biopsy Findings of Myoclonus Body Tamio Ota 1 , Masuyuki Namba 1 1Department of Psychiatry, School of Medicine, Yamaguchi University pp.685-692
Published Date 1966/12/25
DOI https://doi.org/10.11477/mf.1431904362
  • Abstract
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 Brain biopsy from 15-year-old girl patient suffering from myoclonus epilepsy (Lafora type) was performed.

 Biopsied specimen was studied by the light microscope, the phase contrast microscope and the electron microscope.

 Light microscopic examination revealed many Lafora bodies and was completely consistent with the autopsy finding of siblings, already died of myoclonus epilepsy of Lafora type.

 Phase contrast microscopic study disclosed the body consisted of two different layers, i. e. the external and the internal one.

 Electron micrograph of Lafora body revealed that its basic structure was consisted of lamella which composed of double electron dense lines measured about 50 to 100 A thick and electron lucent interspace of similar thickness. Glycogen-like granules of about 250 to 500 A in diameter were scattered throughout the body. Beside the basic lamellar structure, ribosomes, vacuolated rough surfaced endoplasmic reticulum and Golgi apparatus were also found in the large sized body.

 Discussions were performed concerning following items.

 (1) cortex without Lafora body.

 (2) Lafora body in the neuronal perikarya.

 (3) small sized Lafora body.

 (4) structures simulate to Lafora body.

 The relation of abnormal vesicle and the process of Lafora body formation was especially discussed.


Copyright © 1966, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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