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特集 神経病理(第15回日本神経病理学会学術研究会)
シンポジウム関連演題
筋ジストロフィーマウスの末梢神経の超微的病変—坐骨神経を中心として
Ultrastructural abnormalities in the peripheral nerves of the dystrophic mice: A study of the sciatic nerve
岡田 永子
1
,
水平 敏知
1
,
中村 晴臣
2
,
高橋 和郎
2
Eiko OKADA
1
,
Vinci MIZUHIRA
1
,
Haruomi NAKAMURA
2
,
Kazuro TAKAHASHI
2
1東京医科歯科大学難治疾患研究所超微構造部門
2鳥取大学脳幹性疾患研究施設神経病理学教室
1Division of Cell Biology, Medical Research Institute, Tokyo Medical & Dental University
2Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine
pp.447-449
発行日 1975年6月10日
Published Date 1975/6/10
DOI https://doi.org/10.11477/mf.1431903731
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- Abstract 文献概要
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C57 BL/6J-dydyマウス(Dyマウス)の坐骨神経近位部にはBar Harbor 129株Dyマウス同様,巨大な無髄神経集団が認められたので,その部の神経線維数および軸索面積を計測した。
Ultrastructural changes of the sciatic nerves of C 57 BL/6 J-dydy mice were observed in this experiment. Nerve counts were calculated and thearea of axons was measured on the montaged pictures of these nerves. Many large bundles of unmyelinated nerves were observed at the proximal portion of the sciatic nerve, without cytoplasm and basement membrane of the Schwann cell. These bundles composed of axons of various sizes and shapes, including some very large axons. The large unmyelinated axons decreased in number and size as nerves descended to the distal portion. The myelinated nerves showed irregular shapes.
Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.