雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

The fUnctions of ATP receptors expressed in microglia Kazuhide INOUE 1,2 1Division of Pharmacology, National Institute of Health Sciences Keyword: ATP受容体 , ミクログリア , サイトカイン , ケモタキシス pp.533-542
Published Date 2002/8/10
DOI https://doi.org/10.11477/mf.1431901376
  • Abstract
  • Look Inside

The action of ATP mainly on the secretion of plasminogen, TNF-a and IL-6 from microglia was reviewed. ATP (10-100μM) stimulated the release of plasminogen from rat cultured microglia in a concentration-dependent manner with a peak response at 5~10 min after the stimulation. The release was dependent on extracellular Ca2+ and was blocked by pretreatment with oxdisedATP, a blocker of P2X7. ATP potently stimulated TNF-a release from 2 h after the stimulation with TNF-a mRNA expression in primary cultures of rat brain microglia.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有