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Japanese

Therapeutic window for cerebral ischemia Jyoji NAKAGAWARA 1 1Department of Neurosurgery Nakamura Memorial Hospital Keyword: cerebral ischemia , therapeutic window , ischemic penumbra , misery perfusion pp.978-984
Published Date 2001/12/10
DOI https://doi.org/10.11477/mf.1431901313
  • Abstract
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In a case with embolic occlusion of cerebral artery, residual cerebral blood flow (CBF) in symptomatic ischemic region is distributed heterogeneously and cerebral infarction is developed gradually from ischemic core to penum-bra. Ischemic core is defined as a region with irreversible tissue damage due to fairly poor collateral circulation, and ischemic penumbra is defined as a region with preservation of tissue reversibility in a certain time. Reversibil-ity of ischemic penumbra is also depending on both residual CBF and time from stroke onset, and the existence of ischemic penumbra is essential for thrombolytic therapy.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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