Molecular mechanisms of the olfactory sensation and adaptation Takashi KURAHASHI 1,2 1Department of Biophysical Engineering, Osaka University 2Precursory Research for Embryonic Science and Technology(PRESTO), Japan Science and Technology Corporation(JST) Keyword: 嗅細胞 , cAMP , イオンチャネル , 嗅覚順応 pp.729-737
Published Date 1999/10/10
DOI https://doi.org/10.11477/mf.1431901090
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Olfactory signal transduction starts at the ciliary membrane of the receptor cells located in the olfactory epithelium. This transduction is triggered by the G-protein-coupled seven transmembrane receptor, which in turn activates adenylylcyclase-CAMP second messenger system. These chemical reactions finally lead to a sequential opening of cAMP-gated channel and Ca-activatedCl channel. The olfactory receptor cells further convert the graded receptor potential into trains of action potentials which transmit olfactory information to the brain along the axon.

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