Japanese

Molecular mechanisms of the olfactory sensation and adaptation Takashi KURAHASHI 1,2 1Department of Biophysical Engineering, Osaka University 2Precursory Research for Embryonic Science and Technology(PRESTO), Japan Science and Technology Corporation(JST) Keyword: 嗅細胞 , cAMP , イオンチャネル , 嗅覚順応 pp.729-737
Published Date 1999/10/10
DOI https://doi.org/10.11477/mf.1431901090
  • Abstract
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Olfactory signal transduction starts at the ciliary membrane of the receptor cells located in the olfactory epithelium. This transduction is triggered by the G-protein-coupled seven transmembrane receptor, which in turn activates adenylylcyclase-CAMP second messenger system. These chemical reactions finally lead to a sequential opening of cAMP-gated channel and Ca-activatedCl channel. The olfactory receptor cells further convert the graded receptor potential into trains of action potentials which transmit olfactory information to the brain along the axon.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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