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Multiple sclerosis-T cell epitope of myelin antigen and interaction between antigen specific T cells Kohei OTA 1 1Department of Neurology, Neurological Institute, Tokyo Women's Medical College Keyword: 多発性硬化症 , ミエリン塩基性蛋白 , ミエリン抗原特異的T細胞 pp.176-190
Published Date 1997/4/10
DOI https://doi.org/10.11477/mf.1431900936
  • Abstract
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An autoantigen in MS has not been identified, myelin basic protein (MBP), as well as proteolipid apoprotein, has been extensively studied as a potential autoantigen in the disease because it causes experimental autoimmune encephalomyelitis, an animal model for MS. Short term T cell lines were established from patients with multiple sclerosis (MS) and controls in Caucasians to define the T cell specificity toward the human MBP. The higher frequency of T cell lines reactive with a DR2 linked immunodominant region of MBP 84-102 was found in patients with MS as compared to controls.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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