Effects of aging on cerebral circulation and metabolism in man. Kenji ISHII 1 , Michio SENDA 1 1Positron Medical Center, Tokyo Metropolitan Institute of Gerontology Keyword: 老化 , 脳血流 , 脳酸素代謝 , 脳ブドウ糖代謝 pp.794-804
Published Date 1998/10/10
DOI https://doi.org/10.11477/mf.1431900891
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A half century history of the studies regarding aging effect on human cerebral circulation and metabolism was reviewed and several related issues were discussed. Cerebral oxygen metabolism is expected to decline along with aging. No consistent results were reported for the aging effect on cerebral blood flow and cerebral glucose metabolism. The decline of cerebral oxygen metabolism with aging is not linear, but declining from twenties to fifties slowly, then remains relatively stable to eighties. The metabolic change with aging is discrepant with cerebral atrophic change. Morphological and functional evidences revealed that the aging of the brain is not monotonous slowing-down process, but a dynamic process recruiting compensatory mechanisms. The technical variance of the measurements of cerebral circulation and metabolism needs to be improved, and the longitudinal study design will be suitable for observing the aging effect on brain per se.

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