Subcellular localization of the glucocorticoid receptor. Hirotoshi TANAKA 1 , Kensaku OKAMOTO 1 1Second Department of Internal Medicine, Asahikawa Medical College Keyword: 核移行シグナル , 転写因子 , レドックス制御 pp.558-565
Published Date 1998/8/10
DOI https://doi.org/10.11477/mf.1431900870
  • Abstract
  • Look Inside

Glucocorticoids are indispensable for not only maintenance of metabolic homeostasis but also for treatment of a wide variety of human disorders including inflammatory diseases. Glucocorticoids, via binding to the glucocorticoid receptor (GR) in target tissues, exert hormone action. The GR is a ligand-inducible transcription factor, belonging to the nuclear receptor superfamily. Upon binding hormone, the GR dissociates heat shock proteins and translocates into the nucleus, thereby communicating with basal transcriptional machinery, other transcription factors, coactivators and DNA, resulting in the fine tuning of target gene expression.

Copyright © 1998, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院