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Molecular biology of adipocytes Yasutomi Kamei 1 , Yoshihiro Ogawa 1,2 1Department of Molecular Medicine and Metabolism, Medical Research Institute Tokyo Medical and Dental University 2Global COE Keyword: 脂肪細胞 , PPARγ , 転写因子 pp.539-542
Published Date 2011/6/15
DOI https://doi.org/10.11477/mf.1542102639
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Adipocytes as well as myocytes and osteoblasts are considered to be derived and differentiated from mesodermal pluripotent stem cells. The process of adipocyte differentiation was examined intensively using primary cultures and cell lines such as 3T3-L1 preadipocytes, which clarified the molecules involved in the process and their molecular mechanisms (Figure 1). During the process of adipocyte differentiation, various transcription factors coordinately regulate the expression of tissue-specific genes, which cause fat accumulation in the cell. In this review, we will overview the molecular biology of gene regulation in adipocyte differentiation.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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