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Genes of glutamate receptors and the regulation of these expression Haruo OKADO 1 1Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience Keyword: グルタミン酸受容体遺伝子 , 時間空間的発現様式 , 発現変動 , 転写制御機構 pp.290-305
Published Date 1998/4/10
DOI https://doi.org/10.11477/mf.1431900845
  • Abstract
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Glutamate is the major neurotransmitter in the central nervous system. The cDNA clones were obtained by functional cloning technique using oocyte expression system. On the basis of sequence identity, the other glutamate receptors have been molecular cloned. The glutamate-gated cation channels termed ionotropic glutamate receptor; AMPA receptors (G1uR1-4), kainate receptors (G1uR5-7, KA1, 2) delta receptor (delta 1, 2), NMDA receptors (NMDAR1, NMDA2A, 2B, 2C, 2D), Chi receptor (X-1), and the cDNA clones of GTP-binding protein-linked receptor which glutamate activates, termed metabotropic glutamate receptors (mGluR1-8) were isolated.


Copyright © 1998, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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