Bunina body in amyotrophic lateral sclerosis Koichi OKAMOTO 1 1Department of Neurology, Gunma University School of Medicine pp.16-24
Published Date 1996/2/10
DOI https://doi.org/10.11477/mf.1431900716
  • Abstract
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Bunina bodies (BBs) are small eosinophilic intraneuronal inclusions in the remaining lower motor neurons in amyotrophic lateral sclerosis (ALS). BBs are the only pathologically specific hallmark of ALS, and have not been observed in other lower motor neuron diseases. BBs were present almost exclusively in both degenerated and non-degenerated motor neurons, and were frequently seen in patients with a shorter disease duration. Although their fine structures are well known, their nature, origin and significance remain unclear.

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