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Astrocytes in liver diseases. Masaya ODA 1 1Department of Pathology & Neuropathology, Tokyo Metropolitan Neurological Hospital pp.617-629
Published Date 1993/8/10
DOI https://doi.org/10.11477/mf.1431900353
  • Abstract
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1. In the CNS glutamine synthetase (GS) is carried almost selectively in astrocytes, in which the ammonia detoxication is believed to takes place. The GS content is very low in the CNS of new born mice.

2. Hyperammonemia causes characteristic changes of astrocytes, such as Alzheimer II glia and glycogen accumulation in its cytoplasm, processes and nucleus in human autopsy cases of hepatic ence-phalopathies. The immunohistochemical GS-activity is markedly diminished in Alzheimer II glia.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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