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Abnormalities of sleep-wakefulness rhythm during the development of the central nervous system. Masaya SEGAWA 1 1Segawa Neurological Clinic for Children pp.1029-1040
Published Date 1992/12/10
DOI https://doi.org/10.11477/mf.1431900301
  • Abstract
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 Characteristics of abnormal sleep-wakefulness (S-W) cycle occurred during the development of the central nervous system were shown in those of early infantile autism (EIA) and of Gilles de la Tourette syndrome (GTS), and these pathophysiologies and pathognomonic meanings were discussed.

 In EIA, not less than 70% of cases showed abnormal S-W cycle with failure to synchronize the 24 hours day-night cycle. This abnormality was improved by accentuating day time environmental stimulation and the improvement was consolidated by administration of 5-hydroxytryptophan. The adjustment of S-W cycle to the 24 hour day-night cycle preceded improvement of behavioral abnormalities of EIA; lack of social relatedness and insistence on sameness and the ages of the improvement of the cycle, The ages of improvement of S-W cycle were well correlated with those of determination of hand dominancy and development of verbal communications, both of which are delayed in EIA. This disturbances in S-W cycle seemed to develop in early infancy.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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