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Cell adhesion molecules in the development of the cerebellum. Shigeki YUASA 1 , Koki KAWAMURA 1 1Department of Anatomy, School of Medicine, Keio University pp.813-828
Published Date 1992/10/10
DOI https://doi.org/10.11477/mf.1431900277
  • Abstract
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 A variety of cell adhesion molecules play important roles in the processes of cell migration, axonal elongation and synaptogenesis during the development of the central nervous system. In this article, we review the mode of expression and the mechanism of action of cell adhesion moleculesoccurring in the developing cerebellum. Significance of the molecules in the formation of the cortical structure and the development of the neural network are also discussed.

 In the process of migration of granule cells from the external germinal layer into the internal granular layer, migratory granule cells are guided by contact with processes of Bergmann glia. The interaction between neurons and glia are mediated by many cell adhesion molecules such as NCAM, NgCAM (L1), tenascin (cytotactin, J1), astrotactin, adhesion molecule on glia (AMOG), thrombospondin or cerebellar soluble lectin (CSL). The neuronal migration is facilitated by means of cycles of attachment and detachment between neurons and glia. Tissue plasminogen activator is associated with the surface of migratory granule cells and it facilitates the migration by degradation of adhesion molecules by proteolysis through activation of the proteolytic enzyme.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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