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Cerebral ischemia and neuronal cell death. Takaaki KIRINO 1 , Akira TAMURA 1 1Department of Neurosurgery, Teikyo University School of Medicine pp.225-235
Published Date 1992/4/10
DOI https://doi.org/10.11477/mf.1431900227
  • Abstract
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Fatal cerebrovascular disorders has decreased in number gradually, and cerebrovascular diseases (CVD) are no longer the commonest cause of death in Japan since 1981. However, CVD still remain the most frequent disabling disease entity. The brain is particularly susceptible to ischemia. Brain loses its normal function immediately following cessation of cerebral blood supply. It is not fully understood, however, why the loss of normal function following ischemia rapidly shifts to structural breakdown and necrosis of neurons. When cerebral ischemia is severe and prolonged, brain tissue falles into infarction. Neurons and glial cells die in ischemic core region. This pathological process is the typical change in focal cerebral ischemia due to obstruction of major cerebral arteries. When ischemia is transient and brief, even if it is severe, total tissue necrosis does not develop. Neurons are selectively damaged and removed in this case. This selective neuronal necrosis is usually seen in cases with global cerebral ischemia, mostly due to cardiac arrest. Following transient, brief ischemia, the most vulnerable groups of neurons are selectively injured. Pyramidal cells of the hippocampal CA1 sector and Purkinje cells in the cerebellum have been known to be the most susceptible.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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