Multisystem involvement in HTLV-I carriers. Proposal of HTLV-I-associated complex as a clinical entity. Yoshikazu MARUYAMA 1 , Ikuro MARUYAMA 1 , Mitsuhiro OSAME 1 1Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University pp.824-829
Published Date 1991/10/10
DOI https://doi.org/10.11477/mf.1431900179
  • Abstract
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 Human T-lymphotropic virus type I (HTLV-I) causes not only adult T-cell leukemia but also a chronic form of myelopathy called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated tropical spastic paraparesis (TSP). HAM and TSP are now regarded as the same diseases based on their clinical features and virological findings.

 We have been investigating immunologic abnormalities in HAM patients. The patients showed polyclonal hypergammaglobulinemia (mainly IgG and IgA) with markedly increased titer of anti-HTLV-I antibodies in serum and cerebrospinal fluid. Increased IL-I mRNA in the peripheral blood lymphocytes was shown by in situ hybridization.

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