HTLV-I-associated myelopathy (HAM): Clinical neurophysiologic studies. Kimiyoshi ARIMURA 1 , Yukiko ARIMURA 1 , Mitsuhiro OSAME 1 , Raymond L. Rosales 1Department of Internal Medicine, School of Medicine, Kagoshima University pp.961-967
Published Date 1987/12/10
DOI https://doi.org/10.11477/mf.1431905947
  • Abstract
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 Since the recognition of HAM as a new clinical entity, several new cases have been diagnosed throughout Japan. The characteristic features consist of a slowly evolving but progressive course, prominent pyramidal tract signs as against the mild sensory and sphincteric disturbances. The serum and the cerebrospinal fluid show elevated titers of antibody to HTLV-I.

 Perhaps short of pathologic studies in HAM, electrophysiologic studies have potentials of assessing lesion distribution and underlying pathomechanisms. can occur. Short latency somatosensory evoked potentials (SSEP) in median and tibial nerve stimulation did not likewise show abnormalities in the peripheral conductions. However, central conductions, thus the Goll's tract, revealed significant changes. Assessment of regions above the spinal cord, using brainstem auditory evoked potentials (BAEP), visual evoked potentials (VEP) and electrooculography (EOG), suggest that lesions can also spread toward these areas especially in clinically severe cases of HAM. The high frequency of EOG abnormalities in the absence of clinical findings, including the only abnormal case (who also had no brainstem and visual disturbances) in both BAEP and VEP, demonstrates existence of subclinical lesions.

Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.


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