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Alzheimer's disease and neurotrophic factor. Yoko UCHIDA 1 1Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology pp.651-659
Published Date 1990/8/10
DOI https://doi.org/10.11477/mf.1431900061
  • Abstract
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Neuronal loss in cortical and subcortical regions is accompanied by accumulation of senile plaques, neurofibrillary tangles (NFT) and curly fibers in Alzheimer's disease (AD) Recent immunocytochemical studies have suggested that abnormal sprouting may be involved in the formation of senile plaques, NFT and curly fibers. To investigate why abnormal sprouting responses occur in AD brain, we have examined whether neurotrophic activity increases in AD brain extract by using cell culture of neonatal rat cerebral cortex.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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