Shinkei Kenkyu no Shinpo Volume 47, Issue 4 (August 2003)

Paraproteinemic neuropathies Daiji Morita 1 , Susumu Kusunoki 2 1Department of Neurology, School of Medicine, University of Tokyo 2Department of Neurology, Kinki University, School of Medicine Keyword: paraproteinemia , ニューロパチー , MGUS , 骨髄腫 , Crow-Fukase症候群 , Waldenström型マクログロブリン血症 , クリオグロブリン血症 pp.555-562
Published Date 2003/8/10
  • Abstract
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 Neuropathy is known as a frequent complication of paraproteinemia. Although the pathogenesis of the paraproteinemic neuropathy is not fully understood, IgM M-protein in sera from patients with IgM paraproteinemic neuropathies frequently bind to cell surface glycoconjugates and may be directly involved in the pathogenetic mechanisms. Crow-Fukase syndrome(POEMS syndrome)is shown to be associated with the elevated serum level of vascular endothelial growth factor. Patients with monoclonal gammopathy of undetermined significance are usually treated by the methods similar to those used in chronic inflammatory demyelinating polyradiculoneuropathy. In addition to drug therapy, surgery and/or radiation therapy may be necessary in cases with multiple myeloma. Further investigation is needed for clarification of the pathogenesis and the establishment of the treatment of paraproteinemic neuropathies.

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47巻4号 (2003年8月)
電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院