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Response selection and prefrontal cortex Masamichi Sakagami 1,2 1Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency 2Brain Science Research Center, Tamagawa University Research Institute Keyword: 前頭前野 , 霊長類 , 単一ニューロン活動 , 行動決定 pp.502-511
Published Date 2005/8/10
DOI https://doi.org/10.11477/mf.1431100067
  • Abstract
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The prefrontal cortex(PFC)is believed to be a brain region for decision-making, particularly in complex situations. Although some recording studies have shown that prefrontal neurons support decision-making even in simple situations,s ome lesion studies disagree with this view. To understand the role of the PFC, particularly the lateral prefrontal cortex(LPFC), in decision-making, we recorded the neuronal activity from this region while the monkey performed a go/no-go task with a multidimensional stimulus. Each stimulus had two visual dimensions:color and direction of motion;in turn, each dimension had a go feature(e. g., green in the color dimension and upward movement in the motion dimension)and a no-go feature(e. g., red and downward movement, respectively). The monkey was required to attend to one of the visual dimensions in this two-dimensional stimulus. For congruent trials, the monkey was presented with go features both in the relevant and irrelevant dimensions. For the incongruent trials, the monkey was presented with a go feature in the relevant dimension but a no-go feature in the irrelevant dimension. Analyses focused on the activity of neurons that discriminated the go stimulus from the no-go stimulus in the color dimension. For congruent stimuli, we observed no differences in go/no-go differential activity for correct and incorrect trials. For incongruent stimuli, on the other hand, the discrimination of go/no-go differential neurons was correlated with behavioral performance-the lower the discrimination, the lower the performance. Moreover, inactivation study using muscimol micro-injection revealed that the LPFC dysfunction led to decreased performance only in incongruent trials. These results suggest that the brain has several independent pathways to calculate an appropriate behavior for a given situation and that the LPFC output is critical for decision-making only in complex situations. This theory can explain why prefrontal deficits lead to stereotyped behaviors such as imitation and utilization.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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