睡眠薬

Hypnotic Drugs

不眠症は臨床で遭遇する頻度の高い疾患の1つであり半数程度が長期経過をたどる。このため，睡眠衛生指導など非薬物的アプローチをまず行い，慢性化を予防することが求められている。また薬物療法を行う際にも，減薬・休薬がしやすく，転倒や認知機能障害，依存・耐性形成のリスクが低いオレキシン受容体拮抗薬やメラトニン受容体作動薬等の新規睡眠薬を積極的に選択することが望ましい。

Abstract

Insomnia is one of the most frequently encountered diseases in clinical practice, and about half of the patients have a long-term course. Therefore, proactive prevention against chronicity is required, using a non-pharmacological approach for insomnia (sleep hygiene). Pharmacological treatment, needs to decrease the risk of appearance of rebound insomnia, the risk of the patient falling, drug dependence, and cognitive dysfunctions caused by hypnotics. In view of this, it is recommended to use novel sleep medications such as orexin receptor antagonists and melatonin receptor agonists.