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Therapeutic Strategies for Ischemic Stroke Eiichiro Nagata 1 1Department of Neurology, Tokai University School of Medicine Keyword: 抗凝固療法 , 抗血小板療法 , 血栓溶解療法 , 血管内治療 , 脳保護療法 , anticoagulant therapy , antiplatelet therapy , thrombolytic therapy , endovascular therapy , brain protection therapy pp.450-455
Published Date 2023/5/1
DOI https://doi.org/10.11477/mf.1416202358
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Abstract

Ischemic stroke therapy consists of acute phase and preventive treatment strategies. Acute-phase ischemic stroke treatment includes systemic thrombolysis (rt-PA) and mechanical thrombectomy (endovascular therapy). Rt-PA is a very potent thrombolytic agent but its effectiveness is time-dependent. For the prevention of stroke recurrence (secondary stroke prevention) according to the TOAST classification, antiplatelet therapy (aspirin, clopidogrel, and cilostazol) is used for atherothrombotic and lacuna strokes, while anti-coagulant therapy (warfarin and direct oral anticoagulants [DOACs]) are used for cardiogenic cerebral embolism. Additionally, neuroprotective therapy using edaravone, a free radical scavenger, has recently been introduced to minimize brain tissue damage. Recently, neuronal regenerative therapies using stem cells have also been developed.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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