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Rapid Eye Movement Sleep Is Initiated by Dopamine Signaling in the Basolateral Amygdala in Mice Emi Hasegawa 1,2 1Faculty of Medicine, University of Tsukuba 2International Institute for Integrative Sleep Medicine, University of Tsukuba Keyword: 睡眠サイクル , ドーパミン , 扁桃体 , sleep cycle , dopamine , amygdala pp.1303-1308
Published Date 2022/11/1
DOI https://doi.org/10.11477/mf.1416202233
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Abstract

The sleep cycle alternates between REM and NREM sleep, but the mechanisms by which this cycle is generated are totally unknown. We found that a periodic transient increase of the dopamine level in the amygdala during NREM sleep terminates NREM sleep and initiates REM sleep. This mechanism also plays a role in cataplectic attack, which is a pathological intrusion of REM sleep into wakefulness in narcoleptics.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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