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Neural Mechanisms of the Nucleus Accumbens for Flexible and Strategic Decision-Making Takatoshi Hikida 1 1Laboratory for Advanced Brain Functions, Institute for Protein Research, The University of Osaka Keyword: 意思決定 , 柔軟性 , 側坐核 , ドーパミン , 図形識別学習 , decision-making , flexibility , nucleus accumbens , dopamine , visual discrimination pp.789-793
Published Date 2025/7/1
DOI https://doi.org/10.11477/mf.188160960770070789
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Abstract

Decision-making requires flexibility and strategy. Imaging of single-cell-level neural activity and inhibition of neural activity in mice during a visual-discrimination learning task that requires a strategy revealed that dopamine D2 receptor-expressing medium-sized spiny neurons in the nucleus accumbens are important for flexible and strategic decision-making. Single-cell level imaging may be useful in understanding the pathophysiology of neuropsychiatric disorders that impair decision-making flexibility.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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